Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration.

Shijie LiuVaibhav DeshmukhFansen MengYi-Dan Wang Yuka Morikawa Jeffery D Steimle Rich Gang Li Jun Wang James F Martin

Published in: Circulation (2024)

After myocardial infarction, decreased sirtuin activity enriches YAP acetylation at K265. The growing TUBA4A network sequesters acetylated YAP within the cytoplasm, which is detrimental to cardiac regeneration.

Keyphrases

stem cells
heart failure
left ventricular
wound healing
atrial fibrillation