Quantification of Sertraline Fetal-Maternal Ratio and Amniotic Fluid Concentration using a Pregnancy Physiologically Based Pharmacokinetic Model.

David LarteyDanielle JatengMiao LiChristine NguyenVictor CrentsilJulie BeitzBlessy A George

Published in: British journal of clinical pharmacology (2023)

The PBPK model we developed may serve as a guide for maternal sertraline dose adjustment during pregnancy considering changes in exposures for both mother and fetus.

Keyphrases

pregnancy outcomes
birth weight
air pollution
preterm birth
pregnant women
mesenchymal stem cells
body mass index
physical activity
umbilical cord