Parkinson's disease (PD), caused by degeneration of dopaminergic neurons, leads to motor and autonomic symptoms. A large proportion of PD patients experience lower urinary tract symptoms (LUTS) and voiding dysfunction, associated with poor quality of life. Deep brain stimulation (DBS) is an adjunctive therapy used in combination with medication for Parkinsonian motor symptoms and is currently being explored to treat PD-related LUTS. This review discusses the current literature on the effects of DBS on lower urinary tract function and whether this modality can be used to modulate PD-related LUTS and voiding dysfunction.
Keyphrases
- lower urinary tract symptoms
- deep brain stimulation
- benign prostatic hyperplasia
- parkinson disease
- obsessive compulsive disorder
- oxidative stress
- systematic review
- urinary tract
- end stage renal disease
- healthcare
- ejection fraction
- prognostic factors
- stem cells
- heart rate
- chronic kidney disease
- blood pressure
- sleep quality
- depressive symptoms
- bone marrow
- drug induced
- adverse drug
- patient reported