Identification of a novel DNA oxidative damage repair pathway, requiring the ubiquitination of the histone variant macroH2A1.1.

Khalid OuararhniFlore MiettonJamal S M SabirAbdulkhaleg IbrahimAnnie MollaRaed S AlbheyriAli T ZariAhmed BahieldinHervé MenoniChristian BronnerStefan DimitrovAli Hamiche

Published in: BMC biology (2024)

Our data identify a novel pathway for the repair of DNA oxidative lesions, requiring the ubiquitination of mH2A for the release of PARP-1 from chromatin and its activation.

Keyphrases

circulating tumor
dna damage
cell free
single molecule
dna methylation
gene expression
electronic health record
transcription factor
dna repair
genome wide
nucleic acid
big data
oxidative stress
circulating tumor cells
machine learning
artificial intelligence
data analysis