The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson's disease.
Marina PicilloRaffaele PalladinoRoberto ErroRossella AlfanoCarlo ColosimoRoberto MarconiAngelo AntoniniPaolo Baronenull nullPublished in: Journal of neurology (2020)
Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson's disease may impact disease phenotype.