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CircXPO5 Plays a Neuroprotective Function in the Lateral Geniculate Nucleus of Glaucoma by Regulating GRIN2A.

Zhichao YanMingying LaiYu JiaCaibin DengYehong Zhuo
Published in: Brain sciences (2022)
Our earlier studies revealed that the GRIN2A gene regulates the calcium signal pathway. Decreasing of GRIN2A related with neuron apoptosis and neurodegeneration. These findings indicate that the reduction in circXPO5 may have a protective effect on neuronal apoptosis in the visual central system of glaucoma.
Keyphrases
  • endoplasmic reticulum stress
  • oxidative stress
  • cell cycle arrest
  • cell death
  • optic nerve
  • cerebral ischemia
  • copy number
  • genome wide
  • cataract surgery
  • pi k akt
  • dna methylation
  • transcription factor
  • genome wide analysis