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Genetic polymorphism of 20 autosomal short tandem repeats (STRs) in Himachal Pradesh population, India.

Vivek SahajpalAbhishek SinghMukesh ThakurArun SharmaDeepika BhandariLalit Kumar SharmaKailash ChandraSatish Kumar
Published in: International journal of legal medicine (2020)
Genetic diversity indices and forensic parameters at 20 autosomal short tandem repeat (STR) loci were evaluated in 233 unrelated individuals of Himachal Pradesh, India. In total, 255 alleles were observed with an average of 11.25 ± 0.88 alleles per locus. None of the loci deviated from Hardy Weinberg Equilibrium. The most polymorphic and discriminative locus was Penta E. The combined power of exclusion and the combined power of discrimination were found to be 0.99 and 1. Additionally, the genetic relationship of the Himachal Pradesh population with the populations of the neighboring state was also investigated. All the STR loci were found polymorphic, and the select panel of STRs was found suitable for population genetic studies and forensic analysis.
Keyphrases
  • genome wide
  • genome wide association study
  • genetic diversity
  • dna methylation
  • copy number
  • genome wide association
  • molecular dynamics simulations
  • data analysis
  • atomic force microscopy