Serum levels of glial fibrillary acidic protein in patients with amyotrophic lateral sclerosis.
Federico VerdeIlaria MiloneAlessio MaranzanoEleonora ColomboSilvia TorreFederica SolcaAlberto DorettiFrancesco GentileArianna ManiniRuggero BonettiSilvia PeverelliStefano MessinaLuca MadernaClaudia MorelliBarbara PolettiAntonia RattiVincenzo SilaniNicola TicozziPublished in: Annals of clinical and translational neurology (2022)
Our work provides neurochemical evidence of astrocyte involvement in ALS pathophysiology and particularly in the development of extra-motor manifestations (namely, cognitive - memory - impairment) and respiratory dysfunction. The negative correlation between sGFAP and eGFR has practical relevance and should not be disregarded in future investigations.