Disturbed Oligodendroglial Maturation Causes Cognitive Dysfunction in Schizophrenia: A New Hypothesis.
Peter FalkaiMoritz J RossnerFlorian J RaabeElias WagnerDaniel KeeserIsabel MaurusLukas RoellEmily ChangJohanna Seitz-HollandThomas G SchulzeAndrea SchmittPublished in: Schizophrenia bulletin (2023)
Based on these findings, we propose that pro-myelinating drugs (e.g., the histamine blocker clemastine) combined with aerobic exercise training may foster the regeneration of myelin plasticity as a basis for restoring frontotemporal connectivity and cognition in schizophrenia.