Cobalt-Catalyzed Enantioselective Cross-Electrophile Couplings: Stereoselective Syntheses of 5-7-Membered Azacycles.

Zhaoming MaWenqiang XuYun-Dong Wu Jianrong Steve Zhou

Published in: Journal of the American Chemical Society (2023)

Cobalt complexes of chiral pyrox ligands catalyzed enantioselective reductive couplings of nonconjugated iododienes with aryl iodides or alkenyl bromides. The reaction enabled stereoselective syntheses of 5-7-membered azacycles carrying quaternary stereocenters. Mechanistically, cross-electrophile selectivity originated from selective coupling of alkylcobalt(I) complexes generated after cyclization with aryl iodides.

Keyphrases

room temperature
ionic liquid
reduced graphene oxide
metal organic framework
capillary electrophoresis
electron transfer