Delayed Neurological Sequelae Successfully Treated with Adjuvant, Prolonged Hyperbaric Oxygen Therapy: Review and Case Report.
Luca MartaniAndrea GiovannielloGerardo BoscoLuca CantadoriFrancesca CalissiDany FurfaroMassimo PedrazziniRosanna VaschettoEnrico Mario CamporesiMatteo PaganiniPublished in: International journal of environmental research and public health (2022)
Carbon Monoxide (CO) intoxication is still a leading cause of mortality and morbidity in many countries. Due to the problematic detection in the environment and subtle symptoms, CO intoxication usually goes unrecognized, and both normobaric and hyperbaric oxygen (HBO) treatments are frequently administered with delay. Current knowledge is mainly focused on acute intoxication, while Delayed Neurological Sequelae (DNS) are neglected, especially their treatment. This work details the cases of two patients presenting a few weeks after CO intoxication with severe neurological impairment and a characteristic diffused demyelination at the brain magnetic resonance imaging, posing the diagnosis of DNS. After prolonged treatment with hyperbaric oxygen, combined with intravenous corticosteroids and rehabilitation, the clinical and radiological features of DNS disappeared, and the patients' neurological status returned to normal. Such rare cases should reinforce a thorough clinical follow-up for CO intoxication victims and promote high-quality studies.
Keyphrases
- end stage renal disease
- magnetic resonance imaging
- case report
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- healthcare
- early stage
- type diabetes
- computed tomography
- cerebral ischemia
- mesenchymal stem cells
- early onset
- patient reported outcomes
- physical activity
- cardiovascular events
- sleep quality
- hepatitis b virus
- white matter
- smoking cessation
- drug induced
- preterm birth
- resting state
- label free