Role of Glutathione in Chalcone Derivative Induced Apoptosis of Brugia malayi and its Possible Therapeutic Implication.

P S BhojS BahekarV KhatriN SinghN S TogreKalyan GoswamiH S ChandakD Dash

Published in: Acta parasitologica (2020)

We conclude that the depletion of GSH by chalcone with concomitant mitochondrial dysfunction revealed a novel rationale of apoptosis in the parasite. Such a mechanism might have wide therapeutic implications.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
oxidative stress
signaling pathway
cell death
clinical trial
single cell
cell cycle arrest
toxoplasma gondii
plasmodium falciparum
pi k akt
water soluble