Safety, pharmacokinetics, and pharmacodynamics of avoralstat, an oral plasma kallikrein inhibitor: phase 1 study.
M CornpropstP CollisJ CollierY S BabuR WilsonJ ZhangL FangJ ZongWilliam P SheridanPublished in: Allergy (2016)
Avoralstat was well tolerated, and drug exposure was sufficient to meet target levels for inhibition of plasma kallikrein. Based on these results, the 400 mg q8 h dose was selected for further evaluation in patients with HAE.