Amyotrophic lateral sclerosis patients with various gene mutations show diverse motor phenotypes and survival in China.
Qirui JiangJunyu LinQianqian WeiTianmi YangYanbing HouLingyu ZhangRuwei OuYi XiaoShichan WangXiaoting ZhengChunyu LiHui Fang ShangPublished in: Journal of medical genetics (2024)
Our study revealed distinct motor phenotypic tendencies in patients with ALS with different genotypes, indicating variations in the vulnerability of motor neurons during the disease's progression. Furthermore, we made novel discoveries regarding survival of different gene mutations, warranting further investigation.