Central Line-Associated Bloodstream Infection Due to Elizabethkingia anophelis : Case Report and Literature Review on Pediatric Infections.
Sofia MarakiNikolaos KatzilakisIoannis NeonakisDimitra StafylakiViktoria Eirini MavromanolakiIoannis KyriakidisIordanis PelagiadisEftichia StiakakiPublished in: Microorganisms (2024)
Elizabethkingia anophelis is an opportunistic pathogen causing lifethreatening infections in humans, particularly in immunocompromised patients, neonates and the elderly. We report a case of central line-associated bloodstream infection by E. anophelis in a 2.5-year-old girl with acute lymphoblastic leukemia successfully treated with a combination of piperacillin/tazobactam and amikacin. The literature was also reviewed on pediatric infections caused by E. anophelis , focusing on clinical manifestations, underlying medical conditions, treatment and outcome. Accurate identification with MALDI-TOF, or using molecular techniques, is of the utmost importance because treatment and prognosis differ depending on the species. Considering that E. anophelis is multiresistant to antibiotics and that inappropriate antimicrobial therapy is an independent risk factor for mortality, the early, accurate identification of bacterial species and prompt effective treatment are essential to achieve optimal therapeutic outcomes.
Keyphrases
- acute lymphoblastic leukemia
- mass spectrometry
- healthcare
- end stage renal disease
- systematic review
- high resolution
- newly diagnosed
- adipose tissue
- stem cells
- ejection fraction
- metabolic syndrome
- type diabetes
- gram negative
- chronic kidney disease
- peritoneal dialysis
- combination therapy
- preterm infants
- escherichia coli
- klebsiella pneumoniae
- preterm birth
- acute myeloid leukemia
- genetic diversity
- patient reported outcomes