Impact of Latent Tuberculosis on Diabetes.
Burcu TepekuleKatharina KusejkoMarius ZeebPhilip E TarrAlexandra CalmyManuel BattegayHansjakob FurrerMatthias CavassiniEnos BernasconiJulia NotterHuldrych F GünthardJohannes NemethRoger D Kouyosnull nullPublished in: The Journal of infectious diseases (2022)
While an increased risk of active and latent tuberculosis infection (LTBI) in people with type-2 diabetes (DM) has been demonstrated, it is less well characterized whether LTBI is associated with an increased risk of developing DM. We investigated the link between LTBI and DM in people living with HIV in the Swiss HIV Cohort Study via time-dependent Cox proportional hazards models. We found that LTBI significantly increased the risk of developing DM (HR = 1.47), which was robust across different adjustment and censoring techniques. Our results thus suggest that LTBI may be associated with an increased risk of developing DM.
Keyphrases
- glycemic control
- hiv aids
- type diabetes
- mycobacterium tuberculosis
- antiretroviral therapy
- cardiovascular disease
- hiv infected
- human immunodeficiency virus
- hiv positive
- hepatitis c virus
- pulmonary tuberculosis
- hiv testing
- metabolic syndrome
- atomic force microscopy
- skeletal muscle
- high resolution
- weight loss
- single molecule