Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment.
Isabela Pereira GomesJaqueline Aparecida DuarteAna Luiza Chaves MaiaDomenico RubelloDanyelle M TownsendAndré Luís Branco de BarrosElaine Amaral LeitePublished in: Pharmaceuticals (Basel, Switzerland) (2019)
Conventional chemotherapy regimens have limitations due to serious adverse effects. Targeted drug delivery systems to reduce systemic toxicity are a powerful drug development platform. Encapsulation of antitumor drug(s) in thermosensitive nanocarriers is an emerging approach with a promise to improve uptake and increase therapeutic efficacy, as they can be activated by hyperthermia selectively at the tumor site. In this review, we focus on thermosensitive nanosystems associated with hyperthermia for the treatment of cancer, in preclinical and clinical use.
Keyphrases
- cancer therapy
- papillary thyroid
- drug delivery
- squamous cell
- oxidative stress
- squamous cell carcinoma
- high throughput
- big data
- emergency department
- cell therapy
- stem cells
- machine learning
- mesenchymal stem cells
- drug induced
- lymph node metastasis
- drug release
- artificial intelligence
- combination therapy
- deep learning
- oxide nanoparticles