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African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A.

Manjunath SiddappaShahid HussainSajad A WaniJason A WhiteHancong TangJaimie S GrayHedieh JafariHsu-Chang WuMark D LongIsra ElhussinBalasubramanyanam KaranamHonghe WangRebecca MorganGary HardimanIsaacson B AdelaniSolomon Oladapo RotimiBernice OforiLarisa NonnMelissa B DavisRick A KittlesChanita Hughes HalbertLara E Sucheston-CampbellClayton C YatesMoray J Campbell
Published in: Cancer research communications (2023)
Our study identified that genomic ancestry drives the VDR complex composition, genomic distribution, and transcriptional function, and is disrupted by BAZ1A and illustrates a novel driver for AA prostate cancer.
Keyphrases
  • prostate cancer
  • african american
  • radical prostatectomy
  • gene expression
  • copy number
  • transcription factor
  • single cell
  • oxidative stress
  • dna methylation
  • heat shock protein