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Cerebral microhemorrhages in children with congenital heart disease: Prevalence, risk factors, and impact on neurodevelopmental outcomes.

Kristen Nicole AndersenSicong YaoBrian R WhiteMarin JacobwitzJake BreimannJharna JahnaviAlexander SchmidtWesley B BakerTiffany S KoJ William GaynorArastoo VossoughRui XiaoDaniel J LichtEvelyn K Shih
Published in: medRxiv : the preprint server for health sciences (2023)
CMH is a common imaging finding in infants with CHD with increased prevalence and severity after CPB and adverse impact on neurodevelopmental outcomes starting at a young age. Longer duration of CPB and need for postoperative ECMO were the most significant risk factors for developing CMH. However, presence of CMH on preoperative scans indicates non-surgical risk factors that are yet to be identified. Neuroprotective strategies to mitigate risk factors for CMH may improve neurodevelopmental outcomes in this vulnerable population.
Keyphrases
  • risk factors
  • patients undergoing
  • extracorporeal membrane oxygenation
  • magnetic resonance imaging
  • adipose tissue
  • mass spectrometry
  • middle aged
  • insulin resistance
  • respiratory failure
  • blood brain barrier