Circulating nociceptin and CGRP in medication-overuse headache.
Signe Bruun MunksgaardCsaba ErtseyErik FrandsenLars BendtsenKornelia TekesRigmor H JensenPublished in: Acta neurologica Scandinavica (2018)
In contrast to previous findings in migraine patients, we found normal serum levels of nociceptin and CGRP in MOH patients. Thus, we find no evidence that the increased headache frequency of MOH patients could be caused by altered nociceptin and CGRP levels. This underlines the importance of identifying medication overuse in chronic headache and treating the MOH.