Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis.

Rongkun LiYahui WangXiaoxin ZhangMingxuan FengJun MaJun LiXiaomei YangFang FangQiang XiaZhigang ZhangMingyi ShangShu-Heng Jiang

Published in: Molecular cancer (2019)

Taken together, our data demonstrate a novel function of LOXL4 in tumor metastasis mediated by exosomes through regulation of the FAK/Src pathway and angiogenesis in HCC.

Keyphrases

mesenchymal stem cells
stem cells
endothelial cells
electronic health record
tyrosine kinase
vascular endothelial growth factor
cell migration
bone marrow
deep learning
artificial intelligence
data analysis