Immunological risk and complement genetic evaluations in early onset de novo thrombotic microangiopathy after living donor kidney transplantation: a Japanese multicenter registry.

Nobuhiro FujiyamaMasayuki TasakiHiroshi HaradaKoichi TsutaharaAkihiko MatsumotoYuji KamijoMariko ToyodaDaiki IwamiMasashi InuiHiroki ShirakawaJun SugimuraMitsuru SaitoKiyohiko HottaMasayoshi OkumiKazuhide SaitoYoshihiko WataraiYoshihiko HidakaKatsuki OhtaniNorimitsu InoueNobutaka WakamiyaTomonori HabuchiShigeru Satohnull null

Published in: Clinical and experimental nephrology (2023)

Although some immunological risks were found for dnTMA after KTx, only a few cases developed into TMA. The characteristic variations revealed in the present study may be novel candidates related to dnTMA in Japanese or Asian patients, but not pathogenic variants of aHUS. Future studies on genetic and antigenic factors are needed to identify factors contributing to dnTMA after KTx.

Keyphrases

early onset
kidney transplantation
end stage renal disease
copy number
late onset
ejection fraction
genome wide
chronic kidney disease
newly diagnosed
peritoneal dialysis
clinical trial
single cell