White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease.
Seonjoo LeeMolly E ZimmermanAtul NarkhedeSara E NasrabadyGiuseppe TostoIrene B MeierTammie L S BenzingerDaniel S MarcusAnne M FaganNick C FoxNigel J CairnsDavid M HoltzmanVirginia BucklesBernardino GhettiEric McDadeRalph N MartinsAndrew J SaykinColin L MastersJohn M RingmanStefan FӧrsterPeter R SchofieldReisa A SperlingKeith A JohnsonJasmeer P ChhatwalStephen SallowayStephen CorreiaClifford R JackMichael WeinerRandall J BatemanJohn C MorrisRichard MayeuxAdam M Brickmannull nullPublished in: PloS one (2018)
Although there is some co-dependency between WMH and microbleeds, the observed increases in WMH among mutation carriers does not appear to be fully mediated by this marker of CAA. The findings highlight the possibility that WMH represent a core feature of AD independent of vascular forms of beta amyloid.