First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells.

Mohammad Hojjat-FarsangiA H DaneshmaneshA S KhanJ ShetyeF MozaffariP KharazihaL-S RathjeP KokhaeiL HanssonJ VågbergS ByströmE OlssonC LöfbergC NorströmJ SchultzM NorinT OlinA ÖsterborgH MellstedtA Moshfegh

Published in: Leukemia (2018)

Keyphrases

tyrosine kinase
chronic lymphocytic leukemia
cell cycle arrest
small molecule
induced apoptosis
epidermal growth factor receptor
cell death
endoplasmic reticulum stress
oxidative stress
pi k akt
diabetic rats
high glucose
protein protein
signaling pathway
drug induced
cell proliferation
stress induced