NF1 mutation-driven neuronal hyperexcitability sets a threshold for tumorigenesis and therapeutic targeting of murine optic glioma.
Corina AnastasakiJit ChatterjeeJoshua P KoleskeYunqing GaoStephanie L BozemanChloe M KernanLara I Marco Y MarquezJi-Kang ChenCaitlin E KellyConnor J BlairDennis J DietzenRobert A KestersonDavid H GutmannPublished in: Neuro-oncology (2024)
Together, these findings establish midkine and neuronal hyperexcitability as targetable drivers of Nf1-OPG growth and support the use of lamotrigine as a potential chemoprevention or chemotherapy agent for children with NF1-OPG.