Single-Cell Transcriptomic Analyses of Brain Parenchyma in Patients With New-Onset Refractory Status Epilepticus (NORSE).

Aurélie Hanin Le ZhangAnita J HuttnerIsabelle PluBertrand Mathon Franck Bielle Vincent Navarro Lawrence J Hirsch David A Hafler

Published in: Neurology(R) neuroimmunology & neuroinflammation (2024)

Our study sheds light on the complex cellular dynamics in NORSE, revealing the potential roles of microglia, infiltrating macrophages, and astrocytes in hyperexcitability and demyelination, offering potential avenues for future research targeting the identified pathways.

Keyphrases

single cell
rna seq
human health
high throughput
resting state
neuropathic pain
spinal cord injury
climate change
functional connectivity
brain injury
drug delivery
spinal cord