Indole-2-Carboxamide Derivative LG25 Inhibits Triple-Negative Breast Cancer Growth By Suppressing Akt/mTOR/NF-κB Signalling Pathway.
Xiaohong XuVinothkumar RajamanickamSheng ShuZhoudi LiuTao YanJinxin HeZhiguo LiuGuilong GuoGuang LiangYi WangPublished in: Drug design, development and therapy (2019)
Our studies provide experimental evidence that indole-2-carboxamide derivative LG25 effectively targeted TNBC in preclinical models by inducing cell cycle arrest and apoptosis, through suppressing Akt/mTOR/NF-κB signaling pathway.