Can Presepsin Be Valuable in Reducing Unnecessary Antibiotic Exposure after Birth?
Thomas H DierikxHenriëtte van LaerhovenSophie R D van der SchoorCharlotte M NusmanClaire A M LuttermanRoos J S VliegenthartTim G J de MeijMarc A BenningaWes OnlandAnton H van KaamDouwe H VisserPublished in: Antibiotics (Basel, Switzerland) (2023)
Presepsin is a biomarker with an acceptable diagnostic accuracy for EOS (culture-proven and clinical EOS) in preterm infants and might be of value in reducing antibiotic exposure after birth when appended to current EOS guidelines. However, the small number of EOS cases prevents us from drawing firm conclusions. Further research should be performed to evaluate whether appending a presepsin-guided step to current EOS guidelines leads to a safe decrease in antibiotic overtreatment and antibiotic-related morbidity.