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Rapid Access to Aliphatic Sulfonamides.

Mingjun ZhangMo YuZiwen WangYu-Xiu LiuQing-Min Wang
Published in: Organic letters (2022)
Herein, we report a mild, rapid, straightforward method for visible-light-mediated sulfonamide ethylation to afford a diverse array of compounds with C(sp 3 )-sulfonamide skeletons. The method relies on inexpensive, abundant, commercially available primary, secondary, and tertiary alkyl carboxylic acids and alkyl iodides as substrates. The method has a broad substrate scope and potential utility for late-stage functionalization of natural products and synthetic medicines and can be expected to facilitate rapid structural diversification of bioactive molecules.
Keyphrases
  • visible light
  • loop mediated isothermal amplification
  • ionic liquid
  • high resolution
  • risk assessment
  • human health