Detrimental role of SIX1 in hepatic lipogenesis and fibrosis of non-alcoholic fatty liver disease.

Xiaoliang GaoYi ChuWeijie WangWenjiao LiWenyao ZhangJiayi CaoXin FuHui LiuDi ChenDaiming FanYongzhan Nie

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

Our findings suggest a detrimental function of SIX1 in the progression of NAFLD. The direct regulation of LXRα/β and TGF-β signalling by SIX1 provides a new regulatory mechanism in hepatic steatosis and fibrosis.

Keyphrases

liver fibrosis
transcription factor
transforming growth factor
type diabetes
adipose tissue
epithelial mesenchymal transition
skeletal muscle
high fat diet induced