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Heterogeneity in the in vitro susceptibility of Loa loa microfilariae to drugs commonly used in parasitological infections.

Abdel J NjouendouFanny F FombadMaeghan O'NeillDenis ZofouChuck NuttingPatrick C NdongmoArnaud J Kengne-OuafoTimothy G GearyCharles D MackenzieSamuel Wanji
Published in: Parasites & vectors (2018)
The considerable action of the anti-malarial drugs mefloquine and amodiaquine on Loa mf in vitro highlights the possibility of repurposing the existing anti-infectious agents for the development of drugs against loiasis. The heterogeneity in the activity of anti-parasitic agents on Loa loa mf supports the need for further investigation using animal models of loiasis.
Keyphrases
  • single cell