Dimethyl fumarate inhibits antibody-induced platelet destruction in immune thrombocytopenia mouse.

Huan TongYangyang DingXiang GuiZengtian SunGuozhang WangSixuan ZhangZhengqing XuXiamin WangXiaoqi XuWen JuYue LiZhenyu LiLingyu ZengKailin XuJianlin Qiao

Published in: Thrombosis journal (2021)

In conclusion, DMF prevents antibody-mediated platelet destruction in ITP mice possibly through promoting apoptosis, indicating that it might be used as a new approach for the treatment of ITP.

Keyphrases

oxidative stress
endoplasmic reticulum stress
diabetic rats
cell death
high fat diet induced
type diabetes
drug induced
mouse model
skeletal muscle
replacement therapy
endothelial cells