Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.
Chao ZhuQing ZhouZuqiang WangJunyou ZhangCheng XuDike RuanPublished in: Molecular biology reports (2023)
These findings suggest that GDF-5 plays an important role in inhibiting the pyroptosis of NPMSCs and GDF-5 may have potential for degenerative disc disease gene-targeted therapy in the future.
Keyphrases
- risk assessment
- signaling pathway
- human health
- mesenchymal stem cells
- nlrp inflammasome
- pi k akt
- umbilical cord
- epithelial mesenchymal transition
- inflammatory response
- induced apoptosis
- current status
- toll like receptor
- bone marrow
- copy number
- genome wide
- lps induced
- immune response
- stem cells
- cell proliferation
- gene expression
- climate change