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METTL3 drives NSCLC metastasis by enhancing CYP19A1 translation and oestrogen synthesis.
Wangyang Meng
Han Xiao
Rong Zhao
Jiaping Chen
Yangwei Wang
Peiyuan Mei
Hecheng Li
Yongde Liao
Published in:
Cell & bioscience (2024)
Our findings indicate the crucial role of METTL3-mediated translation regulation in NSCLC and reveal the significance of METTL3/eIF4E/CYP19A1 signaling as a promising therapeutic target for anti-metastatic strategies against NSCLC.
Keyphrases
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small cell lung cancer
advanced non small cell lung cancer
brain metastases
squamous cell carcinoma
epidermal growth factor receptor
single cell
gene expression
dna methylation