Variability in benefit from intensive insulin therapy on cardiovascular events in individuals with type 1 diabetes: a post-hoc analysis of the DCCT/EDIC study.
Marga A G HelminkSteven H J HagemanFrank L J VisserenWendela L de Ranitz-GrevenHarold W de ValkThomas T van SlotenJan WesterinkPublished in: Diabetic medicine : a journal of the British Diabetic Association (2023)
Although intensive insulin therapy reduces the risk of MACE in the majority of individuals with type 1 diabetes, benefit varies substantially. These individual differences in the effect of intensive insulin therapy underline the necessity for a better understanding of the individual response to intensive treatment.