VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice.
Farida El GaamouchMickael AudrainWei-Jye LinNoam BeckmannCheng JiangSiddharth HariharanPeter S HeegerEric E SchadtSam GandyMichelle E EhrlichStephen R SaltonPublished in: Molecular neurodegeneration (2020)
These data provide molecular and functional evidence suggesting that mouse and human TLQP-21 modulate microglial function, with potential implications for the progression of AD-related neuropathology.
Keyphrases
- inflammatory response
- endothelial cells
- lipopolysaccharide induced
- signaling pathway
- neuropathic pain
- lps induced
- electronic health record
- high fat diet induced
- induced pluripotent stem cells
- type diabetes
- epithelial mesenchymal transition
- spinal cord injury
- single molecule
- pi k akt
- cell proliferation
- climate change
- endoplasmic reticulum stress