Anti-Müllerian Hormone promotes human osteoblast differentiation and calcification by modulating osteogenic gene expression.
Francesca LiuzziMarilena TaggiSerena De CarliniAntonio La MarcaPublished in: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2023)
Our findings proved interesting clues on the stimulatory effects of AMH on mature osteoblasts expressing its specific receptor, AMHRII. This study may therefore have translation value in opening the perspective that AMH may be an effective candidate to counteract the bone loss in osteoporotic patients by selectively targeting osteoblast with minimal off-target effect.
Keyphrases
- gene expression
- bone loss
- end stage renal disease
- chronic kidney disease
- ejection fraction
- endothelial cells
- newly diagnosed
- mesenchymal stem cells
- dna methylation
- bone marrow
- peritoneal dialysis
- prognostic factors
- bone mineral density
- cancer therapy
- drug delivery
- patient reported outcomes
- body composition
- induced pluripotent stem cells
- patient reported