Methodological approach for determining the Minimal Important Difference and Minimal Important Change scores for the European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module (EORTC QLQ-HN43) exemplified by the Swallowing scale.
Susanne SingerEva HammerlidIwona M TomaszewskaCecilie Delphin AmdalKristin BjordalBente Brokstad HerlofsonMarcos Antônio Dos SantosJoaquim Castro SilvaHisham MehannaAmy FullertonChristine BrannanLoreto Fernandez GonzalezJohanna InhesternMonica PintoJuan Ignacio ArrarasYarom NoamPierluigi BonomoIngo BaumannRazvan GalalaeOurania Nicolatou-GalitisNaomi KiyotaJudith E Raber-DurlacherDina SalemAlexander FabianAndreas BoehmSanja Krejovic-TrivicWei-Chu ChieKatherine J TaylorChristian SimonLisa F LicitraAllen C Shermannull nullPublished in: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation (2021)
For determining MIDs of the remaining scales of the EORTC QLQ-HN43, we will omit comparisons of groups based on the Karnofsky Performance Score. Other external anchors are needed instead. Distribution-based methods worked well and will be applied as a starting strategy for analyses. For the calculation of MICs, subjective change ratings, predictive modelling, and standard-deviation based approaches are suitable methods whereas ROC analyses seem to be inappropriate.