Acute inhibition of iron-sulfur cluster biosynthesis disrupts metabolic flexibility in mice.

Marte MolenaarsHannan MirSamantha W AlvarezLakshmi ArivazhaganCarolina RosselotDi ZhanChristopher Y ParkAdolfo Garcia-OcanaAnn Marie SchmidtRichard L Possemato

Published in: bioRxiv : the preprint server for biology (2024)

Acute ISC inhibition leads to rapid loss of adiposity in miceMulti-metabolic pathway disruption upon ISC deficiency blocks energy storageNfs1 inhibition induces glucose dyshomeostasis due to ISC deficiency in β-cellsEnergy distress caused by inhibition of ISC synthesis is attenuated in aged mice.

Keyphrases

liver failure
high fat diet induced
insulin resistance
intensive care unit
blood glucose
physical activity
replacement therapy
weight gain