Reactivity to neural tissue epitopes, aquaporin 4 and heat shock protein 60 is associated with activated immune-inflammatory pathways and the onset of delirium following hip fracture surgery.
Michael MaesPaul ThisayakornYanin ThipakornSaran TantavisutSunee SirivichayakulAristo VojdaniPublished in: European geriatric medicine (2022)
Increased IgA levels against neuronal self-antigens, AQP4 and HSP60 are risk factors for delirium. Polyreactive antibody-associated breakdown of immune tolerance, IRS activation and injuries in the neuronal cytoskeleton, oligodendrocytes, astrocytes, glial cells, and myelin sheath are involved in the pathophysiology of delirium.
Keyphrases
- hip fracture
- heat shock protein
- heat shock
- induced apoptosis
- minimally invasive
- cell cycle arrest
- oxidative stress
- coronary artery bypass
- cerebral ischemia
- dendritic cells
- cardiac surgery
- endoplasmic reticulum stress
- neuropathic pain
- cell death
- heat stress
- surgical site infection
- spinal cord injury
- coronary artery disease
- acute kidney injury
- cell proliferation
- pi k akt
- percutaneous coronary intervention
- brain injury