Novel DNA methylation biomarkers show high sensitivity and specificity for blood-based detection of colorectal cancer-a clinical biomarker discovery and validation study.

Sarah Østrup JensenNadia ØgaardMai-Britt Worm ØrntoftMads Heilskov RasmussenJesper Bertram BramsenHelle KristensenPeter MouritzenMogens Rørbæk MadsenAnders Husted MadsenKåre Gotschalck SunesenLene Hjerrild IversenSøren LaurbergIb Jarle ChristensenHans Jørgen NielsenClaus Lindbjerg Andersen

Published in: Clinical epigenetics (2019)

TriMeth enables detection of early-stage colorectal cancer with high sensitivity and specificity. The reported results underline the potential utility of DNA methylation-based detection of circulating tumour DNA in the clinical management of colorectal cancer.

Keyphrases

dna methylation
early stage
loop mediated isothermal amplification
label free
real time pcr
gene expression
genome wide
small molecule
single molecule
cell free
radiation therapy
lymph node
copy number
structural basis
sentinel lymph node
human health