Anti-methicillin-resistance Staphylococcus aureus (MRSA) compounds from Bauhinia kockiana Korth. And their mechanism of antibacterial activity.

Yik Ling ChewAdlina Maisarah MahadiKak Ming WongJoo Kheng Goh

Published in: BMC complementary and alternative medicine (2018)

Tannins and polyphenols are the antibacterial components towards MRSA in B. kockiana. Massive leakage of the cell content observed in treated cells showed that the phytochemicals have changed the properties of the cell membranes. Amphiphilic nature of the compounds exhibited the antibacterial activity towards MRSA via three stages: (1) cell membrane attachment; (2) cell membrane fluidity modification; and (3) cell membrane structure disruption.

Keyphrases

staphylococcus aureus
methicillin resistant staphylococcus aureus
single cell
biofilm formation
cell therapy
silver nanoparticles
induced apoptosis
escherichia coli
cell cycle arrest
bone marrow
cystic fibrosis
pseudomonas aeruginosa
cell death
anti inflammatory
pi k akt