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Preventive effects of first-generation antihistamine on emergence agitation or delirium: a systematic review.

Kazumasa KotakeSatoru MatsunumaNaoya KitamuraYumi NoritakeYasuhiro Kawakami
Published in: European journal of clinical pharmacology (2024)
Our results provide limited evidence that some first-generation antihistamines may prevent postoperative emergence agitation and are safe. To further verify this possibility, new RCTs with clear and universal assessment criteria for postoperative emergence agitation or delirium should be conducted.
Keyphrases
  • patients undergoing
  • cardiac surgery
  • hip fracture