MicroRNA regulatory networks associated with abnormal muscle repair in survivors of critical illness.
Christopher J WalshCarlos Escudero KingMuskan GuptaPamela J PlantMargaret J HerridgeSunita MathurPingzhao HuJudy CorreaSameen AhmedAnne BigotClaudia C Dos SantosJane Battnull nullPublished in: Journal of cachexia, sarcopenia and muscle (2022)
Combined functional transcriptomics identified 36 miRs including miRs-424-3p/5p, -490-3p, and -744-5p as potential regulators of gene networks associated with recovery of muscle mass and strength following critical illness. MiR-490-3p is identified as a novel regulator of myogenesis.