Sex Difference in Capillary Reperfusion After Transient Middle Cerebral Artery Occlusion in Diabetic Mice.

Wenbin ZhuCatherine M DavisElyse M AllenSarah L Feller Thierno M Bah Robert E Shangraw Ruikang K Wang Nabil J Alkayed

Published in: Stroke (2023)

DM2 impairs capillary perfusion and exacerbates ischemic deep brain injury in male but not female young adult mice. Premenopausal females appear to be protected against DM2-related capillary dysfunction and brain injury.

Keyphrases

brain injury
cerebral ischemia
middle cerebral artery
subarachnoid hemorrhage
young adults
internal carotid artery
high fat diet induced
oxidative stress
heart failure
type diabetes
glycemic control
computed tomography
metabolic syndrome
left ventricular
magnetic resonance
atrial fibrillation