1-Hydroxypyrene mediates renal fibrosis through aryl hydrocarbon receptor signalling pathway.

Hua MiaoXia-Qing WuYan-Ni WangDan-Qian ChenLin ChenNosratola D VaziriShougang ZhuangYan GuoWei SuShi-Xing MaHuan-Qiao ZhangYou-Quan ShangXiao-Yong YuYan-Long ZhaoJia-Rong MaoMing GaoJin-Hua ZhangJin ZhaoYuan ZhangLi ZhangYing-Yong ZhaoGang Cao

Published in: British journal of pharmacology (2021)

Metabolite 1-hydroxypyrene was demonstrated to mediate renal fibrosis through activation of the aryl hydrocarbon receptor signalling pathway. Targeting aryl hydrocarbon receptor may be an alternative therapeutic strategy for CKD progression.

Keyphrases

drug delivery