Recent progress in the oxidative coupling of unactivated Csp3-H bonds with other C-H bonds.

The oxidative coupling between two carbon-hydrogen (C-H) bonds offers the most straightforward pathway to construct C-C bonds from hydrocarbons without pre-functionalization, exhibiting high step- and atom-economy. This article features the recent advances in the oxidative coupling of unactivated Csp3-H with different hybrid C-H bonds, including Csp-H, Csp2-H and Csp3-H bonds. The substrate scope, proposed mechanism and application of these reactions are summarized, intending to provide insights toward developing novel and efficient protocols for Csp3-C bond construction.