Major Vault Protein Prevents Atherosclerotic Plaque Destabilization by Suppressing Macrophage ASK1-JNK Signaling.

Qingling LiuJunlu PanLinrui BaoChunxiang XuYu QiBin JiangDongdong WangXudong ZhuXiaoyu LiHanwen ZhangHui BaiQing YangJunqing MaErik A C WiemerJingjing BenQi Chen

Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)

MVP may act as an inhibitor for ASK1-JNK signaling-mediated MMP-9 production in macrophages and, thereby, attenuate unstable plaque formation. Our findings suggest that suppression of macrophage ASK1-JNK signaling may be a useful strategy antagonizing atherosclerotic diseases.

Keyphrases

signaling pathway
cell death
induced apoptosis
coronary artery disease
adipose tissue
oxidative stress
small molecule
protein protein
amino acid