Correlation of alterations in the KEAP1/CUL3/NFE2L2 pathway with radiation failure in larynx squamous cell carcinoma.

Siddharth H ShethDouglas R FarquharTravis P SchrankWesley SteppAngela MazulMichele HaywardNicholas R LenzePaul LittleHeejoon JoM Ben MajorBhishamjit S CheraJose P ZevallosD Neil Hayes

Published in: Laryngoscope investigative otolaryngology (2021)

Increased TMB and NFE2L2 pathway alterations were associated with radiation resistance in LSCC. NQO1 mRNA expression may serve as a biomarker for RT response in ES-LSCC.Level of Evidence: II1.

Keyphrases

squamous cell carcinoma
radiation induced
lymph node metastasis
locally advanced
protein protein
small molecule