Upregulated bone morphogenetic protein 5 enhances proliferation and epithelial-mesenchymal transition process in benign prostatic hyperplasia via BMP/Smad signaling pathway.
Daoquan LiuJianmin LiuYan LiHuan LiuHassan M HassanWeixiang HeMingzhou LiYongying ZhouXun FuJunfeng ZhanZhen WangShu YangPing ChenDeqiang XuXinhuan WangMichael E DiSantoGuang ZengXin-Hua ZhangPublished in: The Prostate (2021)
Our novel data suggest that BMP5 modulated cell proliferation and the EMT process through the BMP/Smad signaling pathway which could contribute to the development of BPH. However, further studies are required to determine the exact mechanism. Our study also indicated that BMP/Smad signaling may be rediscovered as a promising new therapeutic target for the treatment of BPH.
Keyphrases
- epithelial mesenchymal transition
- benign prostatic hyperplasia
- signaling pathway
- lower urinary tract symptoms
- transforming growth factor
- mesenchymal stem cells
- pi k akt
- bone regeneration
- cell proliferation
- induced apoptosis
- oxidative stress
- electronic health record
- machine learning
- deep learning
- molecular dynamics
- bone marrow
- smoking cessation
- endoplasmic reticulum stress